Preheat oven to 350. Cook pasta according to package directions
Melt 2 tbsp butter in saucepan over medium heat. Whisk in flour; cook stirring constantly, 1-2 minutes. Gradually whisk in milk, stirring constantly, 3-5 minutes or until thickened.
Stir in Cheddar, salt, and pepper until smooth; add pasta.
Melt 1 tbsp butter in microwave at HIGH 30 seconds. Combine melted putter, Panko breadcrumbs, and Parmesan.
Pour pasta mixture into a greased baking dish; top with Panko mixture.